Chiharu Furukawa Selected Research

ascochlorin

12/2019	4-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition.
6/2009	Ascochlorin activates p53 in a manner distinct from DNA damaging agents.
11/2007	Aberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity.
4/2005	Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines.

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Chiharu Furukawa Research Topics

Disease

3	Neoplasms (Cancer) 12/2019 - 04/2005
2	Osteosarcoma (Osteogenic Sarcoma) 12/2019 - 06/2009
2	Breast Neoplasms (Breast Cancer) 11/2007 - 04/2005
1	Hypoxia (Hypoxemia) 12/2019
1	Polyploidy 03/2019
1	Triple Negative Breast Neoplasms 03/2019
1	Insulin Resistance 07/2009
1	Colonic Neoplasms (Colon Cancer) 06/2009
1	Carcinoma (Carcinomatosis) 11/2007

Drug/Important Bio-Agent (IBA)

4	ascochlorinIBA 12/2019 - 04/2005
2	Proteins (Proteins, Gene)FDA Link 12/2019 - 03/2019
2	Transcription Factors (Transcription Factor)IBA 12/2019 - 11/2007
2	Paclitaxel (Taxol)FDA LinkGeneric 03/2019 - 11/2007
2	DNA (Deoxyribonucleic Acid)IBA 03/2019 - 04/2005
2	Anti-Bacterial Agents (Antibiotics)IBA 06/2009 - 11/2007
2	Estrogen ReceptorsIBA 11/2007 - 04/2005
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 11/2007 - 04/2005
1	4-O-methylascochlorinIBA 12/2019
1	Mixed Function Oxygenases (Monooxygenases)IBA 12/2019
1	IronIBA 12/2019
1	Colchicine FDA LinkGeneric 03/2019
1	NocodazoleIBA 03/2019
1	Vinorelbine (Navelbine)FDA LinkGeneric 03/2019
1	PPAR gammaIBA 07/2009
1	Estrogen Receptor AntagonistsIBA 04/2005

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 11/2007
1	Therapeutics 04/2005